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BCG for Therapeutic Use
- Development stage
- Unknown
- Lead developer
- Chengdu CoenBiotech
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Intravesical
01
Overview
BCG for Therapeutic Use, developed by Chengdu CoenBiotech Co., Ltd, is a live-attenuated strain of *Mycobacterium bovis* used as an intravesical immunotherapy for the treatment and prevention of recurrence of non-muscle invasive bladder cancer (NMIBC). Upon instillation into the bladder, the bacteria attach to the urothelium and are internalized by bladder cancer cells and macrophages, triggering a robust local inflammatory response. This response involves the recruitment of various immune cells, including T lymphocytes, natural killer cells, and macrophages, and the release of Th1-type cytokines, which collectively mediate the destruction of residual tumor cells. It is currently being evaluated in Phase III clinical trials for patients with medium-to-high-risk NMIBC to prevent postoperative recurrence.
- Brand names
- 必赛吉
- Other names
- Bacillus Calmette-GuérinBCG
02
Targets
TLR2 (Toll-like Receptor 2)TLR4 (Toll-like receptor 4)
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