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BCG polysaccharide
- Development stage
- Unknown
- Lead developer
- CG Oncology
- Administration
- Intramuscular, Topical (microneedle Patch)
01
Overview
BCG polysaccharide is an **immunomodulator** extracted from the Bacillus Calmette–Guérin (BCG) vaccine using a hot phenol method, consisting of polysaccharides, nucleic acids, proteins, and lipids. It has been used primarily as an injectable drug to treat immune deficiency diseases including *atopic dermatitis*, *allergic dermatitis*, *systemic lupus erythematosus*, *chronic bronchitis*, *oral lichen planus*, and *asthma*. Its mechanism involves stabilizing mast cells, blocking immunoglobulin function, reducing inflammatory mediator secretion, and enhancing production of interferon-gamma and TNF-alpha by CD4+ T cells, thus exerting anti-allergic and anti-inflammatory effects. It is approved in China as BCG-PSN and has demonstrated better immunotherapeutic outcomes with some novel delivery methods (e.g., microneedle patch) compared to traditional intramuscular injection[2][3][8].
- Brand names
- BCG-PSN
- Other names
- BCG polysaccharide nucleic acidBCG-PSNpolysaccharide nucleic acid fractions of bacillus Calmette–Guérin
02
Targets
CD4 (T lymphocyte surface antigen)
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