Drug intelligence / Profile preview

BCG-Russia + oral polio vaccine

Development stage
Unknown
Lead developer
Serum Institute of India
Modality
Vaccines & Immunotherapeutics
Administration
Intradermal, Oral
01

Overview

BCG-Russia + oral polio vaccine is a combination vaccine intervention consisting of the Russian strain of the live attenuated Bacillus Calmette-Guérin (BCG) vaccine and the live attenuated oral polio vaccine (OPV). This combination was primarily investigated in randomized controlled trials in India to determine if its administration at birth could reduce neonatal mortality in low birth weight infants (weighing <2000 g) through non-specific immune-modulating effects, often referred to as trained immunity. While BCG and OPV are standard vaccines for tuberculosis and poliomyelitis respectively, this specific research focused on their potential to reduce deaths from unrelated infections such as pneumonia and sepsis. Clinical trial results demonstrated that the combination did not significantly impact neonatal mortality rates in the studied population compared to control groups.

Other names
BCG-Russia + OPVBCG-Russia and oral polio vaccine

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