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BCM476

Development stage: Unknown
Lead developer: Shanghai YunSheng YanXin Biotechnology
Modality: Small Molecules
Administration: Oral

Overview

BCM476 is an innovative small molecule therapeutic candidate developed by Shanghai YunSheng YanXin Biotechnology for the management of primary hypertension. It belongs to the Angiotensin Receptor-Neprilysin Inhibitor (ARNI) class, designed to provide a dual mechanism of action by simultaneously inhibiting the enzyme neprilysin (NEP) and blocking the angiotensin II type 1 (AT1) receptor. Inhibition of neprilysin prevents the degradation of natriuretic peptides, thereby enhancing vasodilation, natriuresis, and diuresis, while AT1 receptor antagonism counteracts the vasoconstrictive and fluid-retaining effects of the renin-angiotensin-aldosterone system (RAAS). This synergistic approach is intended to offer more effective blood pressure control and target organ protection compared to traditional antihypertensive agents. BCM476 is currently in Phase 2 clinical development in China.

Other names: BCM476 tabletsBCM-476 tabletsBCM 476 tablets

Targets

AGTR1 (Angiotensin II Type-1 receptor)NEP (Neutral Endopeptidase)

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