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BCMA-BTZ-NPs
- Development stage
- Preclinical
- Lead developer
- Dana-Farber Cancer Institute
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
**BCMA-BTZ-NPs** is a preclinical BCMA-targeted bortezomib nanotherapy for multiple myeloma. It encapsulates the proteasome inhibitor bortezomib in PEG-PLGA nanoparticles functionalized with antibodies against B-cell maturation antigen, enabling selective uptake by BCMA-expressing myeloma cells. In preclinical multiple-myeloma models, the formulation increased tumor-cell internalization, proteasome inhibition, apoptosis, immunogenic cell death, antitumor immune activation, tumor accumulation, and survival relative to free bortezomib or non-targeted bortezomib nanoparticles. Receptor-mediated uptake may also help circumvent P-glycoprotein-associated bortezomib resistance while reducing off-target toxicity.
- Other names
- BCMA-BTZ-Nps
02
Targets
PSMB5 (Proteasome subunit beta Type-5)BCMA (B-cell maturation antigen)
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