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BCMA CAR + CD38 CCR T cells
- Development stage
- Preclinical
- Lead developer
- Vrije University Medical Center
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
BCMA CAR + CD38 CCR T cells is an investigational autologous engineered T-cell therapy being developed by Amsterdam UMC for the treatment of multiple myeloma. The therapy combines a chimeric antigen receptor (CAR) targeting B-cell maturation antigen (BCMA) with a chimeric costimulatory receptor (CCR) targeting CD38. This dual-targeting approach is designed to enhance T-cell activation, proliferation, and persistence while overcoming antigen escape and low antigen density limitations associated with single-target BCMA CAR T-cell therapies. The product is manufactured by transducing patient-derived T cells with a GMP-grade retroviral vector using the Lonza Cocoon platform.
- Other names
- BCMA-CAR+CD38-CCR T cellsBCMA-CAR + CD38-CCR T cells
02
Targets
CD38 (Cluster of Differentiation 38)BCMA (B-cell maturation antigen)
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