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BCMA CAR-CXCR4R334X NK cells
- Development stage
- Preclinical
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
BCMA CAR-CXCR4R334X NK cells are a genetically engineered natural killer (NK) cell therapy designed to treat multiple myeloma. These NK cells are modified to express a chimeric antigen receptor (CAR) that targets B-cell maturation antigen (BCMA), which is highly expressed on malignant plasma cells in multiple myeloma. Additionally, they are engineered to express a mutant CXCR4 receptor (CXCR4^R334X), which enhances the cells' homing and migration toward the bone marrow microenvironment by increasing responsiveness to the chemokine CXCL12/SDF-1α. This modification boosts bone marrow infiltration, in situ activation, and the cytolytic function of NK cells against BCMA-positive tumor cells. Preclinical studies indicate increased anti-myeloma efficacy compared to unmodified or standard BCMA-CAR NK cells. The key mechanistic advantage is enhanced tumor site localization, cytotoxic response, and improved CAR signaling independent of external CXCL12 stimulation.
- Other names
- BCMA CAR-NK-CXCR4R334X cells
02
Targets
CXCR4 (C-X-C motif chemokine receptor 4)BCMA (B-cell maturation antigen)
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