Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
BCMA-GPRC5D CAR-T cells (Donghua Zhang)
- Development stage
- Unknown
- Lead developer
- Donghua Zhang
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
BCMA-GPRC5D CAR-T cells is an investigational dual-targeting chimeric antigen receptor (CAR) T-cell therapy developed by Donghua Zhang at Tongji Hospital. This cell therapy simultaneously targets two antigens highly expressed on malignant plasma cells: B-cell maturation antigen (BCMA) and G protein-coupled receptor class C group 5 member D (GPRC5D). By utilizing a dual-targeting approach, the therapy is designed to enhance anti-tumor activity and mitigate the risk of disease relapse caused by antigen escape, a common limitation of single-target CAR-T therapies. It is currently being evaluated in clinical trials for patients with relapsed or refractory multiple myeloma who have undergone at least three prior lines of treatment.
- Other names
- BCMA-GPRC5D CAR-T cellsBCMA-GPRC-5D CAR-T cellsBCMA-GPRC 5D CAR-T cellsBCMA/GPRC5D dual-targeting CAR-T cellsBCMA-GPRC5D CAR-TBCMA-GPRC-5D CAR-TBCMA-GPRC 5D CAR-T
02
Targets
BCMA (B-cell maturation antigen)GPRC5D
Beyond the preview
Go deeper on BCMA-GPRC5D CAR-T cells (Donghua Zhang).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on BCMA-GPRC5D CAR-T cells (Donghua Zhang).