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BDB-001
- Development stage
- Phase 3
- Lead developer
- Staidson Biopharmaceutical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
BDB-001 is a recombinant human immunoglobulin G4 (IgG4) monoclonal antibody that specifically binds to complement component 5a (C5a), inhibiting C5a-triggered biological functions including neutrophil chemotaxis, intracellular bacteriolysis release, and inflammatory cytokine production. It has also been described as a toll-like receptor 7 and 8 (TLR 7/8) dual agonist with immune modulating capabilities that can reprogram dendritic cells to produce antitumor effects. BDB-001 was developed by Beijing Defengrei Biotechnology and Staidson Beijing BioPharmaceuticals, with primary indications in COVID-19 and advanced solid tumors.
- Other names
- BDB-001 injectionBDB001 injectionBDB 001 injection
02
Targets
TLR8 (Toll-like receptor 8)Complement component C5aTLR7 (Toll-like receptor 7)
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