Drug intelligence / Profile preview

BEACOPP

Development stage
Phase 3
Lead developer
German Hodgkin Study Group
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

BEACOPP is a chemotherapy combination regimen used primarily for treating Hodgkin lymphoma. It consists of seven different medications: * B – Bleomycin: An antibiotic with anti-cancer properties * E – Etoposide: A chemotherapy drug that inhibits DNA synthesis * A – Doxorubicin (also called Adriamycin): An anthracycline that interferes with DNA * C – Cyclophosphamide: An alkylating agent that damages DNA * O – Vincristine (also called Oncovin): A plant alkaloid that disrupts cell division * P – Procarbazine: An alkylating agent * P – Prednisolone/Prednisone: A steroid that reduces inflammation Each drug in this combination works through different mechanisms to destroy cancer cells. BEACOPP has shown significant efficacy in advanced-stage Hodgkin lymphoma, with higher cure rates than some alternative regimens, though it comes with more significant side effects.

Brand names
BEACOPP
Other names
bleomycin + etoposide + doxorubicin + cyclophosphamide + vincristine + procarbazine + prednisoneescalated BEACOPPBEACOPP-baselineescalated-BEACOPP
02

Targets

MicrotubuleTOP2A (DNA topoisomerase II)DNA

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