Drug intelligence / Profile preview

bear bile chuanbei oral liquid

Development stage
Unknown
Lead developer
Pharmesis International
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Bear bile chuanbei oral liquid is a Traditional Chinese Medicine (TCM) formulation developed and marketed by Pharmesis International. It is primarily indicated for the relief of cough and the resolution of phlegm, particularly in conditions associated with 'lung heat' such as acute or chronic bronchitis. The product is a combination of bear bile powder and Fritillaria cirrhosa (Chuanbei). Bear bile is traditionally valued for its anti-inflammatory and antitussive properties, often attributed to bile acids like tauroursodeoxycholic acid (TUDCA). Fritillaria cirrhosa is a staple herb in TCM used to moisten the lungs and clear heat. The product is approved and marketed as an over-the-counter (OTC) medication in China.

Other names
熊胆川贝口服液Xiongdan Chuanbei KoufuyeBear Bile Chuanbei Oral Solution
02

Targets

ABCA1 (ATP-binding cassette transporter A1)GPBAR1NTCP (Na+-taurocholate cotransporting polypeptide)ABCB11 (Bile salt export pump)FXR (Farnesoid x-activated receptor)

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