Drug intelligence / Profile preview

beclometasone dipropionate + formoterol

Development stage
Phase 4
Lead developer
Chiesi
Modality
Small Molecules
Administration
Inhalation
01

Overview

**Beclometasone dipropionate + formoterol** is an inhaled fixed-dose combination of an inhaled corticosteroid and a rapid-onset long-acting beta-2 adrenergic agonist. Beclometasone dipropionate is a prodrug converted in the airways to beclometasone-17-monopropionate, which activates glucocorticoid receptors to suppress airway inflammation. Formoterol activates beta-2 adrenergic receptors on bronchial smooth muscle to produce prolonged bronchodilation. Developed originally by Chiesi as CHF 1535, the combination is supplied in extrafine pressurised metered-dose inhalers and dry-powder inhalers for maintenance treatment of asthma and, in certain products and jurisdictions, symptomatic treatment of severe chronic obstructive pulmonary disease.

Brand names
AeroxAiriamAlabasterBeclo/FormBecloformBibecfoCombairFormodualFostairFostair NEXThalerFosterFoster NEXThalerFostexFostex NEXThalerInnovairInnovair NEXThalerInuvairInuvair NEXThalerInuverInuxairKantosKantos MasterLuforbecProxorVivaire
Other names
BDP/FFbeclomethasone dipropionate + formoterolbeclomethasone dipropionate + formoterol fumaratebeclomethasone dipropionate + formoterol fumarate dihydratebeclomethasone/formoterolbeclometasone dipropionate + formoterolbeclometasone dipropionate + formoterol fumaratebeclometasone dipropionate + formoterol fumarate dihydratebeclometasone/formoterolformoterol + beclometasone dipropionate
02

Targets

ADRB2 (β2)GR (Glucocorticoid receptor)

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