Drug intelligence / Profile preview

beclomethasone

Development stage
Approved
Lead developer
GSK
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation, Intranasal, Topical, Oral
01

Overview

Beclomethasone (also known as beclometasone or beclomethasone dipropionate) is a synthetic glucocorticoid corticosteroid used primarily for its anti-inflammatory and immunosuppressive properties. It is available in several formulations including inhalers (for asthma), nasal sprays (for allergic rhinitis and nasal polyps), creams (for dermatitis and psoriasis), and oral pills (occasionally for ulcerative colitis)[8][3]. The inhaled form is widely used in the long-term management of asthma by reducing airway inflammation and hyper-reactivity[1][2][3]. Its mechanism of action involves binding to the glucocorticoid receptor to inhibit pro-inflammatory signals while promoting anti-inflammatory gene expression[3]. Beclomethasone was first patented in 1962 and approved for medical use in 1976[8].

Brand names
QvarQvar RedihalerBecloventVancerilVanceril DS
Other names
beclometasone dipropionate
02

Targets

GR (Glucocorticoid receptor)ESRRG (Estrogen-related receptor gamma)ESRRA (Estrogen-related receptor alpha)ESRRB (Estrogen-related receptor beta)

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