Drug intelligence / Profile preview

Beclomethasone, Erythromycin, and Furosemide Combination

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Inhalation, Oral
01

Overview

This is a therapeutic regimen consisting of beclomethasone, erythromycin, and furosemide. It was notably documented in a 1995 case report in a 55-year-old woman with bronchorrhea and bronchial asthma, where it effectively managed symptoms, including a significant reduction in sputum volume. The regimen involved oral erythromycin, inhaled beclomethasone, and later, inhaled furosemide. The combination is thought to work through the anti-inflammatory actions of beclomethasone and erythromycin, and the diuretic effect of furosemide, which also improved mucus clearance. It also affected the quality of sputum, altering concentrations of various biochemical markers.

02

Targets

GR (Glucocorticoid receptor)Bacterial 50S ribosomal subunit

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