Drug intelligence / Profile preview

beclomethasone + salbutamol + sodium cromoglycate

Development stage
Unknown
Lead developer
GSK
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation
01

Overview

This is a combination drug consisting of three active pharmaceutical ingredients commonly used in the management of asthma and other obstructive airway diseases: - **Beclomethasone** is a synthetic glucocorticoid corticosteroid that acts as an anti-inflammatory agent, reducing airway inflammation and hyperresponsiveness. - **Salbutamol** (also known as albuterol) is a short-acting beta-2 adrenergic receptor agonist that provides rapid bronchodilation by relaxing bronchial smooth muscle, offering quick relief from acute bronchospasm. - **Sodium cromoglycate** (cromolyn sodium) is a mast cell stabilizer that prevents the release of inflammatory mediators from sensitized mast cells, thereby inhibiting both early and late asthmatic responses to allergens. The combination aims to provide both immediate symptom relief (via salbutamol), long-term control of inflammation (via beclomethasone), and prophylactic stabilization against allergen-induced responses (via sodium cromoglycate). This multi-mechanistic approach may offer superior control for patients with moderate-to-severe or intractable asthma compared to monotherapy[1][2].

02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)

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