bee venom phonophoresis

Bee venom phonophoresis is an investigational therapeutic intervention being studied at Sinai University for the management of knee osteoarthritis. This modality combines the topical application of bee venom (derived from *Apis mellifera*) with ultrasound technology to enhance the transdermal penetration of bioactive compounds into deeper tissues. The primary active components of bee venom, such as melittin and phospholipase A2, exert anti-inflammatory and analgesic effects by inhibiting pathways involving cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). The treatment is currently being evaluated in a randomized controlled trial to assess its efficacy in reducing pain and improving functional mobility and walking endurance in patients with moderate to severe knee osteoarthritis.

Other names

bee venom topical preparationApis mellifera venom phonophoresis