Drug intelligence / Profile preview

beet root extract + arginine + citrulline

Development stage
Unknown
Lead developer
HumanN
Modality
Small Molecules
Administration
Oral
01

Overview

This combination is a dietary supplement formulation designed to enhance nitric oxide (NO) bioavailability through two distinct physiological pathways. Beet root extract serves as a rich source of inorganic nitrates, which are reduced to nitrites by commensal oral bacteria and subsequently converted to nitric oxide in the acidic environment of the stomach or under hypoxic conditions in tissues. L-arginine acts as the primary substrate for the enzyme nitric oxide synthase (NOS), which catalyzes the production of NO and L-citrulline. L-citrulline is included to bypass first-pass metabolism in the liver, effectively increasing systemic L-arginine levels more efficiently than arginine supplementation alone. The synergistic effect is intended to promote vasodilation, improve endothelial function, and enhance exercise performance and cardiovascular health.

Brand names
SuperBeets Heart + CirculationSnap Supplements Nitric Oxide BoosterNature's Pure Blend Nitric Oxide Flow
Other names
Nitric oxide boosterBeetroot with L-arginine and L-citrullineBeetroot extract + L-arginine + L-citrulline
02

Targets

NOS1 (nNOS)sGC (Soluble Guanylyl Cyclase)

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