Drug intelligence / Profile preview

belinostat + 5-fluorouracil

Development stage: Unknown
Lead developer: Assertio
Modality: Small Molecules
Administration: Intravenous

Overview

Belinostat + 5-fluorouracil is an experimental combination therapy for cancer, specifically investigated in renal cell carcinoma and T-cell lymphomas. This regimen combines belinostat, a pan-histone deacetylase (HDAC) inhibitor, with 5-fluorouracil (5-FU), a pyrimidine analog antimetabolite that interferes with DNA synthesis. The combination synergistically induces apoptosis and DNA damage in cancer cells through increased caspase activation, ROS-mediated injury, and attenuation of thymidylate synthase induction (via HSP90 hyperacetylation), enhancing the anticancer effects of 5-FU. This treatment has demonstrated reduction of tumor volume and prolonged progression-free survival in preclinical and early clinical studies in renal cell carcinoma and some T-cell lymphoma patients[1][3][4].

Other names: belinostat + 5-FU

Targets

HDAC (HDAC family)TS (Thymidylate synthase)

Beyond the preview

Go deeper on belinostat + 5-fluorouracil.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on belinostat + 5-fluorouracil.

Explore the full profile