Drug intelligence / Profile preview

belladonna

Development stage
Phase 4
Administration
Oral, Topical, Rectal
01

Overview

Belladonna, also known as Deadly Nightshade or *Atropa belladonna*, is a highly potent and toxic plant that has been historically used in both traditional and homeopathic medicine. Its toxicity stems from tropane alkaloids such as atropine, scopolamine, and hyoscyamine, which are potent anticholinergic agents. In homeopathy, belladonna is prepared in highly diluted forms, such as Belladonna 7cH, and is used based on the principle of "like cures like" to treat conditions with sudden, intense symptoms like fever, inflammation, and pain. A randomized, double-blind, placebo-controlled clinical trial investigated Belladonna 7cH, in association with X-ray 15cH, for the treatment of acute radiodermatitis in breast cancer patients undergoing radiotherapy. The study found a statistically significant benefit of the homeopathic medicine over placebo during the recovery phase, particularly in reducing skin warmth.

Other names
Deadly NightshadeAtropa belladonnaBelladonna 7cHBelladonna7cHBelladonna-7cHBaccifèreBelladoneBelle-DameBelle-GalanteBouton NoirCerise du DiableCerise EnragéeCerise d'EspagneDevil's CherriesDevil's HerbDivaleDwaleDwayberryGrande MorelleGreat MorelGuigne de la CôteHerbe à la MortHerbe du DiableIndian BelladonnaMorelle FurieuseNaughty Man's CherriesPoison Black CherriesSuchi
02

Targets

Glycine receptorADRA2A (α2A)mAChR (Muscarinic acetylcholine receptors)ADRA1D (α1D)Nicotinic acetylcholine receptor alpha5-containing subtypes

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