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Belladonna extract is a botanical extract derived from the leaves and roots of the *Atropa belladonna* (deadly nightshade) plant. It contains active tropane alkaloids, primarily atropine, hyoscyamine, and scopolamine, which function as competitive antagonists of muscarinic acetylcholine receptors. By blocking parasympathetic signaling, belladonna extract exerts antispasmodic, antisecretory, and analgesic effects. It is historically and currently used in various pharmaceutical formulations, such as rectal suppositories, to relieve spasms and pain associated with gastrointestinal disorders, hemorrhoids, and anal fissures. Biosintez is a notable manufacturer of belladonna extract rectal suppositories.
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