Drug intelligence / Profile preview

belladonna extract

Development stage
Unknown
Lead developer
Biosintez
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Rectal, Topical
01

Overview

Belladonna extract is a botanical extract derived from the leaves and roots of the *Atropa belladonna* (deadly nightshade) plant. It contains active tropane alkaloids, primarily atropine, hyoscyamine, and scopolamine, which function as competitive antagonists of muscarinic acetylcholine receptors. By blocking parasympathetic signaling, belladonna extract exerts antispasmodic, antisecretory, and analgesic effects. It is historically and currently used in various pharmaceutical formulations, such as rectal suppositories, to relieve spasms and pain associated with gastrointestinal disorders, hemorrhoids, and anal fissures. Biosintez is a notable manufacturer of belladonna extract rectal suppositories.

Other names
Atropa belladonna extractbelladonna alkaloidsbelladonna leaf extractbelladonna leaves extractdeadly nightshade extractextract of belladonna
02

Targets

Nicotinic Acetylcholine ReceptorHTR3A (5-hydroxytryptamine receptor 3A)mAChR (Muscarinic acetylcholine receptors)

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