benazeprilat

Benazeprilat is the active metabolite of benazepril, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor. It is formed in the liver after oral administration of the prodrug benazepril. Benazeprilat works by competitively inhibiting ACE, thereby blocking the conversion of angiotensin I to angiotensin II—a potent vasoconstrictor—and reducing aldosterone secretion. This leads to vasodilation, decreased blood pressure, and reduced workload on the heart. Benazeprilat is primarily indicated for hypertension and may also be used in heart failure and chronic kidney disease management[5]. Its mechanism helps reduce proteinuria and slow progression of nephropathies.

Other names

(S)-1-ethoxycarbonyl-3-phenylpropyl-L-alanyl-L-prolinebenazeprilat dihydrate