Drug intelligence / Profile preview

bendazac

Development stage
Discontinued
Modality
Small Molecules
Administration
Ophthalmic, Topical, Oral
01

Overview

Bendazac is a non-steroidal anti-inflammatory drug (NSAID) of the oxyacetic acid class, primarily used as an eye drop for the treatment of cataracts and as a topical cream for inflammatory skin conditions such as dermatitis, eczema, hives, and skin ulcers. Its principal mechanism involves inhibiting the denaturation and aggregation of proteins—particularly lens proteins—which helps delay or manage cataract progression. Bendazac also exhibits anti-inflammatory, analgesic, antipyretic, choleretic, antilipidemic, and platelet-inhibitory effects. These actions are partly due to its inhibition of cyclooxygenase (COX) enzymes involved in prostaglandin synthesis. While it has been approved in some regions since 1984 for ophthalmological and dermatological uses (including oral lysine salt formulations), it has been withdrawn or discontinued in many countries due to concerns about hepatotoxicity[1][2][3][5].

Brand names
BendalinaBendaline
Other names
bendazolic acidbendazolic acid, sodium salt2-(1-benzyl-1H-indazol-3-yloxy)acetic acid
02

Targets

CRY (Crystallin family)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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