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benfo-oxythiamine
- Development stage
- Phase 1
- Lead developer
- Benfovir
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Benfo-oxythiamine (B-OT) is an orally bioavailable, lipophilic S-benzoyl-O-monophosphate prodrug of the thiamine antagonist oxythiamine. Developed by Benfovir AG, it is designed to inhibit transketolase, a key enzyme in the pentose phosphate pathway (PPP). By inhibiting transketolase, B-OT disrupts the production of ribose-5-phosphate, which is essential for the synthesis of DNA and RNA. This mechanism aims to suppress the rapid proliferation of cancer cells and the replication of viruses, including SARS-CoV-2. The drug has completed a Phase 1 clinical trial (the BOOST study) in healthy volunteers, which demonstrated a favorable safety and pharmacokinetic profile. Benfovir AG is developing the compound for COVID-19 and other viral infections, while partnering with Oxy5 OncoMedical AG for oncology applications.
- Other names
- S-benzoyl-O-monophosphate oxythiamine
02
Targets
TKT (Transketolase)TKTL1 (Transketolase-like protein 1)PDC (Pyruvate decarboxylase)
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