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Drug intelligence / Profile preview
benfotiamine + mecobalamin + alpha-lipoic acid + folic acid + pyridoxine
- Development stage
- Unknown
- Lead developer
- Solis Pharms
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bentab Plus is an oral fixed-dose combination formulation developed by Solis Pharms, containing benfotiamine (100 mg), mecobalamin (1500 mcg), alpha-lipoic acid (100 mg), folic acid (1.5 mg), and pyridoxine (3 mg). It is primarily indicated for the management of diabetic peripheral neuropathy and other neuropathic conditions. Benfotiamine, a lipid-soluble derivative of thiamine, helps prevent vascular damage by activating the enzyme transketolase and reducing the formation of advanced glycation end-products (AGEs). Mecobalamin, the active form of vitamin B12, promotes nerve regeneration and myelin sheath formation. Alpha-lipoic acid serves as a potent antioxidant that improves endoneurial blood flow and reduces oxidative stress. Folic acid and pyridoxine provide essential cofactors for neurotransmitter synthesis and homocysteine metabolism, further supporting nerve health and function.
- Brand names
- Bentab Plus
- Other names
- Benfotiamine 100mg, Mecobalamin 1500mcg, ALA 100mg, Folic Acid 1.5mg & Pyridoxine 3mg Tablets
02
Targets
MTR (Methionine synthase)TKT (Transketolase)DDC (Aromatic L-amino acid decarboxylase)DHFR (Dihydrofolate reductase)PDH (Pyruvate dehydrogenase complex)
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