benidipine

Benidipine is a synthetic dihydropyridine calcium channel blocker primarily used for the treatment of hypertension and angina pectoris. It acts as a triple calcium channel inhibitor by blocking L-type, N-type, and T-type voltage-dependent calcium channels. This broad inhibition leads to vasodilation and reduced blood pressure. In addition to its antihypertensive effects, benidipine exhibits cardioprotective and renoprotective properties—partly through stimulation of nitric oxide production and suppression of vascular smooth muscle proliferation. Notably, it also functions as an antagonist of the mineralocorticoid receptor (antimineralocorticoid), contributing further to its cardiovascular benefits. Developed in Japan by Kyowa Hakko (now Kyowa Kirin), it is marketed in several Asian countries including Japan and India[1][5][6][7][10].

Brand names

ConielCaritecBeniprime

Other names

benidipine hydrochlorideBenidipinumBenidipinoNacadipineNakadipine