bentazepam

Bentazepam is a thienodiazepine and benzodiazepine analog used primarily as a short-acting anxiolytic. It possesses anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. Its mechanism of action involves acting as a positive allosteric modulator at the GABA-A receptor by binding at the interface between alpha (α) and gamma (γ) subunits—specifically α1, α2, α3, and α5—thereby enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. This results in increased neuronal inhibition leading to its clinical effects. Bentazepam has an oral route of administration with peak plasma concentrations reached approximately 2.5 hours after dosing and an elimination half-life of 2–4 hours. Adverse effects can include dry mouth, somnolence, asthenia, dyspepsia, constipation, nausea; rare but serious risks include drug-induced lymphocytic colitis and severe liver damage[1][4][6].

Brand names

Tiadipona

Other names

bentazepamthiadiponetiadipona