Drug intelligence / Profile preview

Benza Block

Development stage
Unknown
Lead developer
Alinamin Pharmaceutical
Modality
Small Molecules
01

Overview

Benza Block is a line of over-the-counter, designated Class 2 cold medicines marketed in Japan that combine the nonsteroidal anti-inflammatory drug ibuprofen with various antihistamines, sympathomimetic decongestants, antitussives, mucolytics, and ancillary agents to relieve multiple symptoms of the common cold, including fever, sore throat, nasal congestion, runny nose, cough, phlegm, headache, chills, and musculoskeletal pain. Different Benza Block variants (such as IP, L, L Premium, and YASUMO) adjust ingredient ratios and add components like tranexamic acid for mucosal inflammation, l-carbocysteine or guaifenesin for sputum, pseudoephedrine or dl-methylephedrine for nasal and bronchial symptoms, and first-generation antihistamines such as chlorpheniramine or diphenhydramine to control rhinorrhea and sneezing while, in some nighttime formulas, omitting caffeine to avoid insomnia.[1][2][3][4][6][7]

Brand names
Benza Block
02

Targets

ADRA1A (α1A)MOR (Mu opioid receptor)HRH1 (Histamine H1 Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ADOR (Adenosine receptors)

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