Drug intelligence / Profile preview

benzocaine + lidocaine + tetracaine

Development stage
Phase 4
Lead developer
AstraZeneca
Modality
Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration
Topical
01

Overview

Benzocaine + lidocaine + tetracaine is a compounded topical anesthetic cream containing three local anesthetics—benzocaine (an ester-type), lidocaine (an amide-type), and tetracaine (an ester-type). It is primarily used to provide local dermal anesthesia for minor procedures such as laser hair removal, electrolysis, or other dermatological interventions. The mechanism of action involves reversible blockade of sodium ion channels in neuronal membranes, thereby inhibiting the initiation and conduction of nerve impulses and resulting in localized numbness or loss of sensation at the site of application. This combination is typically prepared by compounding pharmacies when commercial products are unavailable or unsuitable[1][2][4][6].

Brand names
Super TEnznonuty
Other names
BLTBLT creamBLT skin cream
02

Targets

RYR2 (Ryanodine receptor 2)NaV alpha (Voltage-gated sodium channel alpha subunit family)

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