benzoyl peroxide + adapalene + clindamycin

**Benzoyl peroxide + adapalene + clindamycin** is a fixed-dose topical triple-combination acne therapy marketed as **Cabtreo** and developed by **Bausch Health**. The gel contains **clindamycin phosphate 1.2%**, **adapalene 0.15%**, and **benzoyl peroxide 3.1%** and is used for the topical treatment of **acne vulgaris**. Its mechanism is multimodal: clindamycin provides antibacterial and anti-inflammatory activity against acne-associated bacteria, benzoyl peroxide exerts antibacterial oxidizing and keratolytic effects, and adapalene is a retinoid that modulates retinoic acid receptor signaling to normalize follicular keratinization and reduce comedone formation and inflammation. It is a once-daily **topical gel** and represents the first FDA-approved triple-combination topical product for acne vulgaris.

Brand names

Cabtreo

Other names

benzoyl peroxide + adapalene + clindamycinclindamycin phosphate + adapalene + benzoyl peroxide