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Benzyl nicotinate is a small molecule vasodilator and rubefacient. It is the benzyl ester of nicotinic acid (niacin), formed by the condensation of the carboxy group of nicotinic acid with benzyl alcohol. Benzyl nicotinate is primarily used in topical preparations—often in combination with analgesics—for the treatment of muscle, joint, and ligament pain. Its mechanism involves local vasodilation and increased blood flow to the skin when applied topically. It has also been used in creams, baths, and emulsions for both human and veterinary medicine[1][2][5][8].
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