benzylpenicilloyl polylysine

Benzylpenicilloyl polylysine is a diagnostic agent used as a skin test antigen to assess sensitization to penicillin (benzylpenicillin or penicillin G) in patients suspected of having clinical penicillin hypersensitivity. It is a conjugate of the major antigenic determinant of penicillin (the benzylpenicilloyl group, which acts as a hapten) covalently bound to the carrier protein poly-L-lysine. When injected intradermally or subcutaneously, it reacts with specific IgE antibodies in sensitized individuals, triggering the release of chemical mediators and producing an immediate-type hypersensitivity reaction if present. This test helps identify patients at risk for allergic reactions to therapeutic doses of penicillin[1][2][3][4][5]. **Developers:** AllerQuest **Manufacturers:** AllerQuest, ALK-Abelló

Brand names

Pre-Pen

Other names

benzyl penicilloyl-polylysinebenzylpenicilloyl G polylysine