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berberine + gamma-cyclodextrin
- Development stage
- Unknown
- Lead developer
- EuroPharma
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Oral
01
Overview
**Berberine + gamma-cyclodextrin** is an oral combination formulation intended to increase the bioavailability and clinical effectiveness of berberine, a plant alkaloid used to support healthy blood sugar, cholesterol, triglyceride levels, and metabolic health. Gamma-cyclodextrin acts as a molecular carrier, forming an inclusion complex with berberine that significantly improves its solubility and intestinal absorption, addressing the well-documented low bioavailability of free berberine (typically less than 5%). This results in a more effective plasma concentration of berberine at lower doses. The combination is under clinical evaluation to determine its pharmacokinetic profile and metabolic benefits, particularly for metabolic syndrome and related disorders[1][2][3][5][9].
- Brand names
- Berberine MetX Ultra Absorption
- Other names
- Berberine + GCDBerberine + gamma-cyclodextrin inclusion complex
02
Targets
SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)AMPK (Adenosine monophosphate–activated protein kinase)
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