Drug intelligence / Profile preview

berberis aristata

Development stage
Unknown
Lead developer
Indena
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical, Ophthalmic
01

Overview

*Berberis aristata*, commonly known as Indian barberry or Daruharidra, is a medicinal shrub native to the Himalayan region of India and Nepal. It is a member of the Berberidaceae family and is highly valued in traditional medicine systems such as Ayurveda and Siddha. The plant is a prolific source of protoberberine alkaloids, with berberine being its primary bioactive constituent. Research indicates that *Berberis aristata* extracts possess pleiotropic pharmacological activities, including lipid-lowering, antidiabetic, antimicrobial, and anti-inflammatory effects. It is frequently utilized in nutraceutical formulations to manage metabolic syndrome, hypercholesterolemia, and type 2 diabetes by normalizing glucose metabolism and lipid profiles. Furthermore, it has demonstrated potential in oncology for its ability to inhibit cancer cell migration and induce apoptosis in various cell lines, as well as in treating gastrointestinal disorders like chronic diarrhea.

Other names
Indian barberryDaruharidraMaramanjalChutroDarviIndian berberry
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)PCSK9 (Proprotein convertase subtilisin/kexin type 9)Misfolded SOD1BDNF (Brain-derived neurotrophic factor)CYP2D6 (Cytochrome P450 2D6)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)AcetylcholinesteraseCYP3A4 (Cytochrome P450 3A4)ABCB1 (P-glycoprotein)CYP1A2 (Cytochrome P450 1A2)LDLR (Low-density lipoprotein receptor)Neuraminidase

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