Drug intelligence / Profile preview

Bergacyn

Development stage
Unknown
Lead developer
DolCas Biotech
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Bergacyn is a patented oral botanical nutraceutical developed by DolCas Biotech for metabolic and liver health support, particularly in non-alcoholic fatty liver disease, metabolic syndrome, and obesity-related metabolic dysfunction. It is a combination product composed of bergamot polyphenolic fraction derived from *Citrus bergamia* and wild Calabrian artichoke thistle extract from *Cynara cardunculus*, standardized to contain at least 17% bergamot polyphenols and 5% cynaropicrin, and produced using a solvent-free extraction and co-grinding process. Rather than acting through a single defined molecular target typical of pharmaceuticals, Bergacyn appears to exert multimodal antioxidant, anti-inflammatory, lipid-lowering, vasculoprotective, and hepatometabolic effects that have been evaluated in randomized, double-blind, placebo-controlled clinical studies, including reduction of hepatic steatosis and improvement in vascular and metabolic parameters at a typical studied dose of 600 mg/day.

Brand names
BergacynBergacyn FF
Other names
bergamot polyphenolic fraction + Cynara cardunculus extract
02

Targets

NF-κBAMPK (Adenosine monophosphate–activated protein kinase)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

Beyond the preview

Go deeper on Bergacyn.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on Bergacyn.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call