Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
bergamot extract
- Development stage
- Unknown
- Lead developer
- AKHYNEX
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Bergamot extract is a natural, flavonoid-rich botanical extract derived from the juice and albedo of the bergamot orange (*Citrus bergamia* Risso), a citrus plant grown primarily in the Calabria region of Southern Italy. It is widely used as a dietary supplement and nutraceutical for the management of mild-to-moderate dyslipidemia, hypercholesterolemia, and metabolic syndrome. The extract contains a unique profile of bioactive polyphenolic flavonoids, including naringin, neoeriocitrin, neohesperidin, melitidin, and brutieridin. Bergamot extract exerts its lipid-lowering and metabolic effects through multiple mechanisms, primarily by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (similar to statins) and activating AMP-activated protein kinase (AMPK), which downregulates cholesterol and fatty acid synthesis while improving glucose homeostasis and insulin sensitivity.
- Brand names
- BergamonteBergavitEndobergKalita
- Other names
- bergamot juice extractbergamot phytocomplexbergamot polyphenolic extractbergamot polyphenolic fractioncitrus bergamia extractcitrus bergamia risso extract
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)AMPK (Adenosine monophosphate–activated protein kinase)
Beyond the preview
Go deeper on bergamot extract.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on bergamot extract.