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bet v 1 birch pollen allergen extract
- Development stage
- Unknown
- Lead developer
- Universität Leipzig
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
Bet v 1 birch pollen allergen extract is a biologic allergen immunotherapy (AIT) agent consisting of the natural major allergen from birch pollen (*Betula verrucosa*). It is administered via subcutaneous injection (SCIT) to desensitize patients with birch pollinosis. The primary rationale for its use in the BASALIT (Birch Associated Soy Allergy and Immuno-Therapy) trial is to treat pollen-food allergy syndrome, specifically the immediate-type soy allergy caused by cross-reactivity between the birch allergen Bet v 1 and the soy allergen Gly m 4. By modulating the IgE-mediated immune response and inducing immunological tolerance, the extract aims to reduce allergic symptoms triggered by both birch pollen and soy consumption.
- Other names
- Bet v 1birch pollen allergen extractnatural Bet v 1 protein
02
Targets
Bet v 1Bet v 1-sIgE (Bet v 1-specific IgE)
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