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beta blocker + digoxin + amiodarone (Hospital Clínic de Barcelona)
- Development stage
- Unknown
- Lead developer
- Hospital Clínic of Barcelona
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a pharmacological combination regimen consisting of a beta blocker, digoxin, and amiodarone, used for heart rate control in patients with permanent atrial fibrillation. It was utilized as a comparator arm in the SPARE III (NCT01181414) Phase 4 clinical trial conducted by the Hospital Clinic of Barcelona. The regimen targets the atrioventricular (AV) node through multiple mechanisms: beta blockers antagonize adrenergic receptors, digoxin inhibits the Na+/K+-ATPase pump to slow AV nodal conduction via vagal effects, and amiodarone acts as a class III antiarrhythmic with multi-channel blocking properties. This combination is typically reserved for refractory cases where single or dual-agent therapy fails to achieve adequate rate control.
- Other names
- beta blocker + digoxine + amiodaronedrug-based rate control
02
Targets
ADRB1 (β1)ADRB2 (β2)SCN5A (Sodium channel protein type 5 subunit alpha)LTCC (Voltage-gated calcium channel (L-type))KCNH2 (Voltage-gated potassium channel subfamily H member 2)KCNQ1 (Potassium voltage-gated channel subfamily KQT member 1)ATP1A (Sodium/potassium-transporting ATPase)
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