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beta-citronellol
- Development stage
- Preclinical
- Lead developer
- Thomas Jefferson University
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
Beta-citronellol is a naturally occurring monoterpene found in cannabis and various essential oils, such as rose and geranium oil. In respiratory research, it has demonstrated significant bronchodilatory effects by relaxing pre-contracted airway smooth muscle (ASM) tissues. The mechanism of action involves the inhibition of myosin light chain 20 (pMLC20) phosphorylation, a key process in muscle contraction. Additionally, beta-citronellol has been shown to work cooperatively with beta-2 adrenergic receptor (B2AR) agonists, such as isoproterenol, to enhance airway relaxation. These findings suggest that beta-citronellol may have therapeutic potential as an adjunct treatment for asthma and other obstructive airway diseases.
- Other names
- citronellol3,7-dimethyl-6-octen-1-ol
02
Targets
MYL9 (Myosin light chain 9)ADRB2 (β2)
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