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beta-D-galactosamine
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
beta-D-Galactosamine is an amino sugar and a deoxygalactose derivative, specifically a hexose monosaccharide in which the hydroxy group at position 2 of beta-D-galactose is replaced by an amino group. It occurs as a metabolite in Escherichia coli and is functionally related to beta-D-galactose. In experimental settings, galactosamine (including the D-form) is used to induce liver injury in animal models by interfering with uridine nucleotide pools essential for RNA and protein synthesis. This hepatotoxic effect results from its metabolism via the Leloir pathway, leading to depletion of uridine triphosphate (UTP) and other uridine derivatives necessary for cellular function[1][6]. There are no approved medical indications or clinical uses for this compound as a pharmaceutical agent[2].
- Other names
- Galactosamine, beta-D-14196-86-2K8YZM765ZSK-8YZM765ZSK 8YZM765ZS
02
Targets
P2RY2 (P2Y Purinoceptor 2)
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