Drug intelligence / Profile preview

beta-pinene

Development stage
Preclinical
Modality
Small Molecules
Administration
Inhalation, Oral, Topical
01

Overview

beta-Pinene is a naturally occurring bicyclic monoterpene and a structural isomer of alpha-pinene, found as a major constituent in conifers (turpentine), various essential oils, and cannabis. While not an approved pharmaceutical drug, it is a widely studied small molecule research compound known for its antimicrobial, anti-inflammatory, and potential anticancer biological activities. Its mechanism of action involves partial agonism of the CB1 and CB2 cannabinoid receptors, as well as inhibition of cyclooxygenase (COX) enzymes and acetylcholinesterase. Recent academic research has also identified its ability to relax airway smooth muscle and significantly potentiate the bronchodilatory effects of beta-2 adrenergic receptor agonists like isoproterenol, suggesting therapeutic potential for respiratory conditions such as asthma. Additionally, beta-pinene serves as a chemical scaffold for the synthesis of novel derivatives with enhanced activity against pathogens like MRSA and *Candida albicans*.

Other names
beta-Pinene(-)-beta-Pinene(+)-beta-Pinene2(10)-Pinene6,6-dimethyl-2-methylenebicyclo[3.1.1]heptaneCAS 127-91-3CAS127-91-3CAS-127-91-3
02

Targets

ADRB2 (β2)CNR1 (Cannabinoid receptor 1)AcetylcholinesteraseCOX

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