Drug intelligence / Profile preview

Beta-sitosterol

Development stage
Phase 2
Modality
Small Molecules
Administration
Oral
01

Overview

Beta-sitosterol is a plant-derived sterol (phytosterol) structurally similar to cholesterol. It is found in many fruits, vegetables, nuts, and seeds. Beta-sitosterol works primarily by inhibiting the absorption of cholesterol in the intestines, leading to reduced serum cholesterol levels. This mechanism makes it useful for managing hyperlipidemia and associated cardiovascular risks. Additionally, beta-sitosterol has been used to improve symptoms of benign prostatic hyperplasia (BPH), though it does not shrink the prostate gland itself. Other investigated effects include immunomodulatory and potential anticancer properties as well as antioxidant activity[1][2][3][4][6].

Brand names
ProstasalTriastonalAzuprostatHarzol
Other names
phytosterolplant sterolβ-sitosterol
02

Targets

NPC1L1 (Niemann-pick C1-Like 1 transporter)

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