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Drug intelligence / Profile preview
betacellulin
- Development stage
- Preclinical
- Lead developer
- Gregorio Marañón University General Hospital
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intranasal, Subcutaneous
01
Overview
Betacellulin (BTC) is a recombinant protein and a member of the epidermal growth factor (EGF) family that acts as an agonist for the epidermal growth factor receptor (EGFR/ErbB1) and ErbB4. It is being investigated as a regenerative, secretome-derived therapy for post-ischemic brain repair and neural regeneration following ischemic stroke. In preclinical models, intranasal or osmotic pump administration of recombinant betacellulin promotes neural stem/progenitor cell activation, neurogenesis, and angiogenesis, leading to reduced infarct size and improved behavioral recovery.
- Other names
- BTCprobetacellulinrecombinant betacellulinrecombinant human betacellulin
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)ERBB4 (Erb-b2 receptor tyrosine kinase 4)EGFR (Epidermal growth factor receptor)
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