Drug intelligence / Profile preview

betamethasone + fusidic acid

Development stage
Unknown
Lead developer
LEO Pharma
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Betamethasone + fusidic acid is a topical combination drug containing two active ingredients: betamethasone (usually as the valerate ester), a potent synthetic corticosteroid with anti-inflammatory and immunosuppressive properties; and fusidic acid, an antibiotic that inhibits bacterial protein synthesis. This combination is primarily used to treat inflammatory skin conditions such as eczema or dermatitis when these are also infected by bacteria sensitive to fusidic acid. Betamethasone reduces redness, swelling and itching by blocking the production of pro-inflammatory chemical messengers (prostaglandins), while fusidic acid prevents bacterial growth by inhibiting essential protein synthesis in susceptible organisms[1][2][4][6][9].

Brand names
FucicortFusiderm-BFutop-BFuzi BFusibact BFusacortFusigen BFucigud BClodic BFusitop B
Other names
betamethasone valerate + fusidic acid
02

Targets

GR (Glucocorticoid receptor)EF-G (Elongation factor G 1, mitochondrial)

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