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betamethasone + bupivacaine + Reparel knee sleeve
- Development stage
- Unknown
- Lead developer
- University of Alabama at Birmingham
- Modality
- Small Molecules
- Administration
- Intraarticular, Topical
01
Overview
This combination intervention is being evaluated by the University of Alabama at Birmingham for the management of knee osteoarthritis. It consists of a multimodal approach involving an intra-articular injection of betamethasone (a corticosteroid) and bupivacaine (a local anesthetic) combined with the use of a Reparel™ knee sleeve. The Reparel™ sleeve is a Class I medical device that utilizes bioactive, thermo-active compression technology designed to improve blood flow and reduce inflammation. The corticosteroid component, betamethasone, provides potent anti-inflammatory effects by activating glucocorticoid receptors, while bupivacaine offers immediate analgesic relief by blocking voltage-gated sodium channels. The clinical trial (NCT04859764) aims to determine if this combination therapy results in superior mobility, functionality, and pain outcomes compared to standard corticosteroid injections paired with a placebo sleeve.
- Brand names
- Reparel
- Other names
- Corticosteroid Injection Plus Reparel Knee Sleeve
02
Targets
NaV (Voltage-gated sodium channels)GR (Glucocorticoid receptor)
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