Drug intelligence / Profile preview

betamethasone + gentamicin + miconazole

Development stage
Unknown
Lead developer
KLONAL Laboratorios
Modality
Small Molecules
Administration
Topical
01

Overview

Miklogen is a topical combination pharmaceutical product developed and marketed by the Argentine company KLONAL Laboratorios. It is formulated as a cream containing three active ingredients: betamethasone (as 17-valerate), gentamicin (as sulfate), and miconazole (as nitrate). This combination is indicated for the treatment of various inflammatory dermatoses where secondary bacterial or fungal infections are present or suspected. Betamethasone, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive actions. Gentamicin is a broad-spectrum aminoglycoside antibiotic that offers bactericidal activity against common skin pathogens, including *Staphylococcus aureus* and *Pseudomonas aeruginosa*. Miconazole is an imidazole antifungal agent that disrupts fungal cell membrane integrity by inhibiting the synthesis of ergosterol. As a generic marketed product in Argentina, Miklogen is commonly used for conditions such as infected eczema, seborrheic dermatitis, and contact dermatitis.

Brand names
Miklogen
Other names
Miklogen Crema
02

Targets

GR (Glucocorticoid receptor)CYP51A1 (Sterol 14α-demethylase)Bacterial RibosomeMR (Mineralocorticoid receptor)

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