Drug intelligence / Profile preview

betamethasone + loratadine

Development stage
Phase 4
Lead developer
Merck
Modality
Small Molecules
Administration
Oral
01

Overview

**betamethasone + loratadine** is a combination drug consisting of two active pharmaceutical ingredients: betamethasone, a synthetic glucocorticoid corticosteroid, and loratadine, a non-sedating antihistamine. The drug is primarily used as an oral solution for the short-term treatment of severe perennial allergic rhinitis and acute exacerbations of allergic rhinitis, especially in pediatric patients. Betamethasone provides potent anti-inflammatory effects by inhibiting pro-inflammatory mediators and suppressing immune responses; loratadine acts as a selective antagonist of the Histamine H1 receptor, reducing symptoms like sneezing, nasal congestion, and pruritus. Clinical studies have demonstrated superior efficacy of the combination over monotherapy for acute allergic symptoms, with good safety for short-term use.

Brand names
Claricort
Other names
loratadine and betamethasone combination
02

Targets

SLC6 (SLC6 family)GR (Glucocorticoid receptor)HRH1 (Histamine H1 Receptor)

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