Drug intelligence / Profile preview

betamethasone dipropionate + cefuroxime

Development stage
Unknown
Lead developer
Shionogi
Modality
Reversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical, Oral, Intravenous, Intramuscular, Otic
01

Overview

Betamethasone dipropionate + cefuroxime is a combination drug consisting of betamethasone dipropionate, a potent synthetic glucocorticoid corticosteroid, and cefuroxime, a second-generation cephalosporin antibiotic. Betamethasone dipropionate acts by binding to the glucocorticoid receptor and modulating gene expression to suppress inflammation and immune responses. Cefuroxime exerts its antibacterial effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell lysis and death. This combination may be used in clinical settings where both anti-inflammatory and antibacterial actions are desired, such as certain skin or ear infections where inflammation coexists with bacterial infection[3][4][6][8][10].

02

Targets

GR (Glucocorticoid receptor)PBP (Penicillin-binding protein family)

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