betamethasone dipropionate spray 0.05%

DFD-01 is a novel topical formulation of betamethasone dipropionate, specifically as a 0.05% emollient spray or lotion, developed for the treatment of mild to moderate plaque psoriasis. It is classified as a mid-potency corticosteroid and was designed to optimize skin penetration while minimizing systemic absorption and side effects typical of higher potency steroids[1][2][4]. The mechanism of action involves agonism at the glucocorticoid receptor, leading to anti-inflammatory and immunosuppressive effects in psoriatic lesions[5][7]. Clinical studies have shown that DFD-01 provides efficacy comparable to superpotent corticosteroids (such as Diprolene) but with an improved safety profile suitable for longer-term use[1][2][8]. The vehicle formulation also enhances skin barrier function and flexibility[4].

Brand names

Sernivo

Other names

betamethasone dipropionate 0.05% sprayDFD01DFD-01DFD 01