Drug intelligence / Profile preview

betamethasone sodium phosphate + bromfenac + tetracycline hydrochloride

Development stage
Preclinical
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Ophthalmic
01

Overview

This is a combination drug consisting of three active pharmaceutical ingredients: - **Betamethasone sodium phosphate** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. It acts by binding to the glucocorticoid receptor, modulating gene expression, and suppressing the production of inflammatory mediators. It is used to treat various inflammatory conditions, including ocular inflammation[5][6][7]. - **Bromfenac** is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis and controlling pain and inflammation. Bromfenac is commonly used in ophthalmology for postoperative inflammation. - **Tetracycline hydrochloride** is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It treats or prevents bacterial infections. The combination may be formulated for ophthalmic use (such as eye drops), targeting postoperative or acute ocular inflammation where both anti-inflammatory action (from betamethasone and bromfenac) and infection prophylaxis/treatment (from tetracycline) are required.

02

Targets

GR (Glucocorticoid receptor)Bacterial RibosomePTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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