Drug intelligence / Profile preview

betamethasone valerate + mupirocin

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Betamethasone valerate + mupirocin is a topical combination drug used primarily to treat skin conditions characterized by both inflammation and bacterial infection. Betamethasone valerate is a synthetic corticosteroid that reduces inflammation, itching, redness, and swelling by suppressing the immune response and inhibiting the production of inflammatory mediators such as prostaglandins. Mupirocin is a topical antibiotic that inhibits bacterial protein synthesis by binding to bacterial isoleucyl-tRNA synthetase, effectively killing susceptible bacteria (notably Staphylococcus aureus and Streptococcus pyogenes) on the skin. This combination provides dual action—anti-inflammatory effects from betamethasone valerate and antibacterial effects from mupirocin—making it effective for conditions like infected eczema, impetigo with inflammation, infected contact dermatitis, secondarily infected psoriasis, wounds with secondary infection, lichen planus with superimposed infection, among others[1][2][3][4]. It is available in cream or ointment formulations for topical use.

Other names
betamethasone + mupirocinbetamethasone valerate and mupirocin
02

Targets

IleRS (Isoleucyl-tRNA synthetase)GR (Glucocorticoid receptor)

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